منابع مشابه
Mammalian mirtron genes.
Mirtrons are alternative precursors for microRNA biogenesis that were recently described in invertebrates. These short hairpin introns use splicing to bypass Drosha cleavage, which is otherwise essential for the generation of canonical animal microRNAs. Using computational and experimental strategies, we now establish that mammals have mirtrons as well. We identified 3 mirtrons that are well co...
متن کاملThe Mirtron Pathway Generates microRNA-Class Regulatory RNAs in Drosophila
The canonical microRNA (miRNA) pathway converts primary hairpin precursor transcripts into approximately 22 nucleotide regulatory RNAs via consecutive cleavages by two RNase III enzymes, Drosha and Dicer. In this study, we characterize Drosophila small RNAs that derive from short intronic hairpins termed "mirtrons." Their nuclear biogenesis appears to bypass Drosha cleavage, which is essential ...
متن کاملThe biogenesis and characterization of mammalian microRNAs of mirtron origin
Mirtrons, short hairpin pre-microRNA (miRNA) mimics directly produced by intronic splicing, have recently been identified and experimentally confirmed in invertebrates. While there is evidence to suggest several mammalian miRNAs have mirtron origins, this has yet to be experimentally demonstrated. Here, we characterize the biogenesis of mammalian mirtrons by ectopic expression of splicing-depen...
متن کاملMirtron microRNA-1236 inhibits VEGFR-3 signaling during inflammatory lymphangiogenesis.
OBJECTIVE Vascular endothelial growth factor receptor(VEGFR)-3 is a critical regulator of developmental and adult vasculogenesis and lymphangiogenesis through its interactions with select members of the VEGF family. The goal of this study was to investigate how VEGFR-3 expression is regulated during inflammatory lymphangiogenesis. METHODS AND RESULTS In this study, we present for the first ti...
متن کاملIntroducing the
The “organizer paper” by Hans Spemann and Hilde Mangold (1924) initiated a new epoch in developmental biology. It marked the climax of Spemann’s life-long research, and the “organizer effect” received special mention by the committee that honoured him with the Nobel Prize for physiology and medicine in 1935. This introduction precedes a translation of that paper by Spemann’s student, Viktor Ham...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2007
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg2170